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Feverfew (Tanacetum parthenium L. Schultz-Bip.)
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Feverfew/Drug Interactions:- AbortifacientsAbortifacients: Traditional use suggests that feverfew may have abortifacient effects.
- Antiangiogenic drugsAntiangiogenic drugs: Theoretically, feverfew may have additive effects when taken concomitantly with antiangiogenic drugs (7).
- Antiarthritic agentsAntiarthritic agents: In vitro and animal studies have shown that feverfew possess anti-inflammatory activity (11; 74; 75; 76; 77; 78; 79; 80; 81; 82). Therefore, feverfew may theoretically increase the anti-inflammatory effects of antiarthritic agents.
- AntibioticsAntibiotics: In an in vitro study, the essential oil of feverfew (Tanacetum parthenium) demonstrated bactericidal activities against most of the microorganisms tested, with Gram-positive species exhibiting significantly lower sensitivity relative to Gram-negative species. (83). With respect to Gram-positive species, the essential oil exhibited strong bactericidal effects on only Bacillus species, but exhibited strong bactericidal action against nearly all Gram-negative species.
- AnestheticsAnesthetics: Based on a review, feverfew may cause complications when used concomitantly with anesthetics (22).
- Anticoagulant and antiplateletsAnticoagulant and antiplatelets: Feverfew has been shown to inhibit platelet secretory and aggregation activity, and may theoretically increase the risk of bleeding if used concomitantly with anticoagulant or antiplatelet agents (71; 66; 67; 68; 69; 70; 22). Feverfew has been demonstrated to inhibit prostaglandins (72; 73). It has also been shown to interact with aspirin (53).
- Antidepressant agents, selective serotonin reuptake inhibitors (SSRIs)Antidepressant agents, selective serotonin reuptake inhibitors (SSRIs): Based on animal study, it has been suggested that feverfew may worsen symptoms of depression or reduce the effectiveness of antidepressants. Serotonin 5-HT receptor blocking effects have been suggested as a possible mechanism of action for feverfew in the treatment of migraine headaches (84).
- AntifungalsAntifungals: In an in vitro study, the essential oil of feverfew (Tanacetum parthenium) demonstrated fungicidal activities (83). A strong antifungal effect was noted in five of the eight fungal species investigated, and the essential oil exhibited strong effects against the molds and dermatophytes tested in the study.
- AntihistaminesAntihistamines: Feverfew extract has demonstrated a dose-dependent inhibition of histamine release from stimulated rat peritoneal mast cells (85). Therefore, feverfew may theoretically have additive effects when taken with antihistamines.
- Anti inflammatory agentsAnti inflammatory agents: In vitro and animal studies have shown that feverfew possess anti-inflammatory activity (11; 74; 75; 76; 77; 78; 79; 80; 81; 82).
- Antineoplastic agentsAntineoplastic agents: Based on in vitro studies, parthenolide, a constituent of feverfew, may have inhibitory activity against cancer cell lines (9; 14), and may enhance the chemotherapy activity of paclitaxel (8).
- AntiprotozoalsAntiprotozoals: In an in vitro study, parthenolide showed significant activity against the promastigote form of Leishmania amazonensis (18). Therefore, feverfew may theoretically have additive effects when taken with antiprotozoals.
- Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Feverfew has been seen to possess inhibitory effects on the CYP enzymes. Specific isoenzymes studied were CYP1A2/2C8/2C9/2C19/2D6 and 3A4 (86).
- Gastrointestinal agents, miscellaneousGastrointestinal agents, miscellaneous: Feverfew may cause oral inflammation and ulceration, swelling of the lips, loss of taste (21), tongue soreness (31), gingival bleeding, indigestion, nausea, flatulence, constipation, diarrhea, abdominal bloating, heartburn (27), and diarrhea (29).
- Neurologic agentsNeurologic agents: Based on animal study, it has been suggested that feverfew may worsen symptoms of depression or reduce the effectiveness of antidepressants. Serotonin 5-HT receptor blocking effects have been suggested as a possible mechanism of action for feverfew, in the treatment of migraine headaches (84).
- Photosensitizing agentsPhotosensitizing agents: Feverfew may increase the risk of photosensitivity (22).
- VasodilatorsVasodilators: Extracts of feverfew and parthenolide have been reported to inhibit smooth muscle contractility (87), and strongly inhibit responses to phenylephrine, 5-hydroxytryptamine, thromboxane mimetic and angiotensin II (88). Blockade of open potassium channels has been suggested in animal studies (89; 90).
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Feverfew/Herb Interactions:- AbortifacientsAbortifacients: Traditional use suggests that feverfew may have abortifacient effects.
- AnestheticsAnesthetics: Based on a review, feverfew may cause complications when used concomitantly with anesthetics (22).
- Antiangiogenic herbsAntiangiogenic herbs: Theoretically, feverfew may have additive effects when taken concomitantly with antiangiogenic agents (7).
- Antiarthritic herbs and supplementsAntiarthritic herbs and supplements: In vitro and animal studies have shown that feverfew possess anti-inflammatory activity (11; 74; 75; 76; 77; 78; 79; 80; 81; 82). Therefore, feverfew may theoretically increase the anti-inflammatory effects of antiarthritic herbs and supplements.
- AntibacterialsAntibacterials: In an in vitro study, the essential oil of feverfew (Tanacetum parthenium) demonstrated bactericidal activities against most of the microorganisms tested, with Gram-positive species exhibiting significantly lower sensitivity relative to Gram-negative species (83). With respect to Gram-positive species, the essential oil exhibited strong bactericidal effects only on Bacillus species, but exhibited strong bactericidal action against nearly all Gram-negative species.
- Anticoagulants and antiplatelets herbsAnticoagulants and antiplatelets herbs: Feverfew has been shown to inhibit platelet secretory and aggregation activity, and may theoretically increase the risk of bleeding if used concomitantly with anticoagulant or antiplatelet agents (71; 66; 67; 68; 69; 70; 22). Feverfew has been demonstrated to inhibit prostaglandins (72; 73).
- Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): Based on animal study, it has been suggested that feverfew may worsen the symptoms of depression or reduce the effectiveness of antidepressants. Serotonin 5-HT receptor blocking effects have been suggested as a possible mechanism of action for feverfew in the treatment of migraine headaches (84).
- AntifungalsAntifungals: In an in vitro study, the essential oil of feverfew (Tanacetum parthenium) demonstrated fungicidal activities (83). A strong antifungal effect was noted in five of the eight fungal species investigated, and the essential oil exhibited strong effects against the molds and dermatophytes tested in the study.
- AntihistaminesAntihistamines: Feverfew extract has demonstrated a dose-dependent inhibition of histamine release from stimulated rat peritoneal mast cells (85). Therefore, feverfew may theoretically have additive effects when taken with antihistamines.
- Anti inflammatory herbsAnti inflammatory herbs: In vitro and animal studies have shown that feverfew possess anti-inflammatory activity (11; 74; 75; 76; 77; 78; 79; 80; 81; 82).
- AntineoplasticsAntineoplastics: Based on in vitro studies, parthenolide, a constituent of feverfew, may have inhibitory activity against cancer cell lines (9; 14), and may enhance the chemotherapy activity of paclitaxel (8).
- AntiparasiticsAntiparasitics: In an in vitro study, parthenolide showed significant activity against the promastigote form of Leishmania amazonensis (18). Therefore, feverfew may theoretically have additive effects when taken with antiparasitics, particularly antiprotozoals.
- Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Feverfew has been seen to possess inhibitory effects on the CYP enzymes, specific isoenzymes studied were CYP1A2/2C8/2C9/2C19/2D6 and 3A4 (86).
- Garlic(Allium sativum)Garlic(Allium sativum): In theory, feverfew may increase the risk of bleeding when taken with garlic.
- Gastrointestinal herbs and supplementsGastrointestinal herbs and supplements: Feverfew may cause oral inflammation and ulceration, swelling of the lips, loss of taste (21), tongue soreness (31), gingival bleeding, indigestion, nausea, flatulence, constipation, diarrhea, abdominal bloating, heartburn (27), and diarrhea (29). Therefore, feverfew may theoretically interact with gastrointestinal herbs or supplements.
- Ginkgo(Ginkgo biloba)Ginkgo(Ginkgo biloba): In theory, feverfew may increase the risk of bleeding when taken with ginkgo.
- Neurologic herbs and supplementsNeurologic herbs and supplements: Based on an animal study, it has been suggested that feverfew may worsen symptoms of depression or reduce the effectiveness of antidepressants. Serotonin 5-HT receptor blocking effects have been suggested as a possible mechanism of action for feverfew, in the treatment of migraine headaches (84).
- PhotosensitizersPhotosensitizers: Feverfew may increase the risk of photosensitivity (22).
- Vasodilator herbs and supplementsVasodilator herbs and supplements: Extracts of feverfew and parthenolide have been reported to inhibit smooth muscle contractility (87), and strongly inhibit responses to phenylephrine, 5-hydroxytryptamine, thromboxane mimetic, and angiotensin II (88). Blockade of open potassium channels has been suggested in animal studies (89; 90).
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Feverfew/Food Interactions:- Insufficient available evidence.
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Feverfew/Lab Interactions:- Coagulation panelCoagulation panel: Feverfew has been shown to inhibit platelet secretory and aggregation activity, and may theoretically increase the risk of bleeding if used concomitantly with anticoagulant or antiplatelet agents (71; 66; 67; 68; 69; 70). Feverfew has been demonstrated to inhibit prostaglandins (72; 73). It has also been shown to interact with aspirin (53).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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